Flovent HFA comes as an inhaler with a separate metal canister containing the medication. 2 Do not use the Flovent inhaler with other medications. Do not use other inhalers with the Flovent canister. Clean your Flovent inhaler once per week. 4 Use a clean, damp cotton swap to clean the small opening where the medicine sprays out. Wipe the mouthpiece with a damp, clean tissue and allow the inhaler to air dry. Throw away the canister and inhaler when the counter reads 000. You have used all the medication. Store your Flovent HFA at room temperature (68˚F and 77˚F). Avoid high heat or flames.
Fluticasone propionate is a highly selective agonist at the glucocorticoid receptor with negligible activity at androgen , estrogen , or mineralocorticoid receptors , thereby producing anti-inflammatory and vasoconstriction effects. It has been shown to have a wide range of inhibitory effects on multiple cell types (. mast cell , eosinophil , neutrophil , macrophages , and lymphocytes ) and mediators (. histamine , eicosanoids , leukotrienes , and cytokines ) involved in inflammation . Fluticasone propionate is stated to exert a topical effect on the lungs without significant systemic effects at usual doses, due to its low systemic bioavailability .
In rabbits, fetal weight reduction and cleft palate were observed at a fluticasone propionate dose approximately times the MRHDID for adults (on a mg/m² basis at a maternal subcutaneous dose of 4 mcg/kg/day). However, no teratogenic effects were reported at fluticasone propionate doses up to approximately 20 times the MRHDID for adults (on a mg/m² basis at a maternal oral dose up to 300 mcg/kg/day). No fluticasone propionate was detected in the plasma in this study, consistent with the established low bioavailability following oral administration [see CLINICAL PHARMACOLOGY ].