First trimester: Ibuprofen should not be used during the first trimester of pregnancy (first 3 months) unless the potential benefit to the patient outweighs the potential risk to the unborn baby.
Second trimester: Ibuprofen should not be used during the second trimester of pregnancy (from 3-6 months) unless the potential benefit to the patient outweighs the potential risk to the unborn baby.
Third trimester: Ibuprofen is not safe to use in the third trimester (last 3 months) of pregnancy because it may delay the start and increase the duration of labour and increase the risk of bleeding in mother and baby.
The prefix “nano” is derived from the Greek word dwarf (Thassu et al., 2007). One nanometer (nm) is equivalent to one-billionth of a meter. Materials in the nanometer size range can have substantial properties compared with the same materials at a larger size, for instance materials in the micrometer size range (Hans and Lowman, 2002). The term “nanotechnology” was coined in 1974 by Norio Taniguchi, a professor of the Tokyo Science University, Japan to describe materials in nanometers (Kydonieu, 1992). In recent years, nanotechnology has gained much attention that there has been an increasing investment trend from governments and private sector business in many parts of the world to expand research in nanoscale science and technology.
NSAIDS have antipyretic activity and can be used to treat fever.   Fever is caused by elevated levels of prostaglandin E2 , which alters the firing rate of neurons within the hypothalamus that control thermoregulation.   Antipyretics work by inhibiting the enzyme COX, which causes the general inhibition of prostanoid biosynthesis ( PGE2 ) within the hypothalamus .   PGE2 signals to the hypothalamus to increase the body's thermal set point.   Ibuprofen has been shown more effective as an antipyretic than paracetamol (acetaminophen).   Arachidonic acid is the precursor substrate for cyclooxygenase leading to the production of prostaglandins F, D & E.