Intralesional corticosteroids for alopecia areata

Many men with Peyronie’s disease are anxious about the appearance of their penis, for obvious reasons. Some might feel worried about not being able to satisfy their partner or even fathering a child, due to difficulties having intercourse. The loss of intimacy and the relationship problems due to Peyronie’s disease can strongly affect one’s psychological well-being. [ 1,2 ] That is why it is important to be open about these feelings, however difficult it might be. Here are some tips/guidelines for talking to your partner about Peyronie’s disease.

Chronic friction is a common etiological cause of lichen amyloidosis and treatment is usually directed at relieving the associated pruritus. Sedating antihistamines may help with relieving the itch, not because of their inherent antihistamine effects, but because of their inherent sedating qualities. Intralesional steroids may be useful alone or in combination with other modalities including topical steroids , topical tacrolimus and even treatment with UVB phototherapy may help alleviate the pruritus. Systemic acitretin can be effective, but only as long as the patient continues the therapy. Surgical excision and dermabrasion of isolated lesions can be performed.

Intralesional fluorouracil (50 mg per mL, two to three times per week) appears to shrink keloids safely while avoiding the tissue atrophy and telangiectasia that may occur with repeated corticosteroid injections. 30 Combining fluorouracil with corticosteroid injections and pulsed dye laser produced superior results more rapidly than corticosteroid injections alone or corticosteroids with fluorouracil. 13 Good to excellent responses at 12 weeks as rated by a blinded observer were 15 percent for triamcinolone acetonide, 40 percent for triamcinolone plus fluorouracil, and 70 percent for all three modalities (all significant). Combining corticosteroids and fluorouracil diminished the adverse effects of corticosteroids. Rare skin complications of fluorouracil may include hyperpigmentation and wound ulceration. No systemic adverse effects (., anemia, leucopenia, thrombocytopenia) occurred in this study.

Cicatricial alopecia is hair loss resulting from a condition that damages the scalp and hair follicle 7 ( Figure 5 ) . In addition to a bald spot, the scalp usually has an abnormal appearance. Plaques of erythema with or without scaling or pustules may be present. Conditions that can be associated with cicatricial alopecia include infections (., syphilis, tuberculosis, acquired immunodeficiency syndrome, herpes zoster), autoimmune disease (discoid lupus erythematosus), sarcoidosis, scalp trauma (., injuries, burns), and radiation therapy. 7

Intralesional corticosteroids for alopecia areata

intralesional corticosteroids for alopecia areata

Cicatricial alopecia is hair loss resulting from a condition that damages the scalp and hair follicle 7 ( Figure 5 ) . In addition to a bald spot, the scalp usually has an abnormal appearance. Plaques of erythema with or without scaling or pustules may be present. Conditions that can be associated with cicatricial alopecia include infections (., syphilis, tuberculosis, acquired immunodeficiency syndrome, herpes zoster), autoimmune disease (discoid lupus erythematosus), sarcoidosis, scalp trauma (., injuries, burns), and radiation therapy. 7

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