Nasal corticosteroid spray over the counter

It is likely that much of the mechanism for the anti-allergic and anti-inflammatory effects of mometasone furoate lies in its ability to inhibit the release of mediators of allergic reactions. Mometasone furoate significantly inhibits the release of leukotrienes from leucocytes of allergic patients. In cell culture, mometasone furoate demonstrated high potency in inhibition of synthesis and release of IL-1, IL-5, IL-6 and TNFα; it is also a potent inhibitor of leukotriene production. In addition, it is an extremely potent inhibitor of the production of the Th2 cytokines, IL-4 and IL-5, from human CD4+ T-cells.

Mometasone furoate increased chromosomal aberrations in an in vitro Chinese hamster ovary-cell assay, but did not increase chromosomal aberrations in an in vitro Chinese hamster lung cell assay. Mometasone furoate was not mutagenic in the Ames test or mouse- lymphoma assay, and was not clastogenic in an in vivo mouse micronucleus assay and a rat bone marrow chromosomal aberration assay or a mouse male germ -cell chromosomal aberration assay. Mometasone furoate also did not induce unscheduled DNA synthesis in vivo in rat hepatocytes.

Both FLONASE® and Nasacort® 24 Hour nasal spray are OTC corticosteroid nasal sprays that relieve nasal allergy symptoms, including congestion. FLONASE® Allergy Relief, however, contains what—until going over-the-counter—has been the #1-prescribed allergy medicine by doctors.** Plus, FLONASE® Allergy Relief was the first OTC nasal allergy spray indicated to provide 24-hour relief of both nose- and eye-related allergy symptoms. So, if itchy, watery eyes are a problem for you during spring allergy season, FLONASE® Allergy Relief can provide you with the ocular symptom relief you need to be greater than your allergies.

Nasal corticosteroid spray over the counter

nasal corticosteroid spray over the counter

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