As soon as the Laboratory Results are matched with a DCF in ADAMS, the Adaptive Model is automatically applied to detect Atypical Passport Findings(ATPFs). The Adaptive Model is an algorithm that calculates whether the result, or results over time in the case of a longitudinal profile, is likely the result of a normal physiological condition. An Atypical Passport Finding (ATPF) is generated in ADAMS if the athlete’s T/E ratio is out of the individual range generated by the Adaptive Model to a specificity of 99%. An Atypical Passport Finding (ATPF) requires further investigation.
As a glucocorticoid , the lipophilic structure of prednisolone allows for easy passage through the cell membrane where it then binds to its respective glucocorticoid receptor (GCR) located in the cytoplasm. Upon binding, formation of the GC/GCR complex causes dissociation of chaperone proteins from the glucocorticoid receptor enabling the GC/GCR complex to translocate inside the nucleus. This process occurs within 20 minutes of binding. Once inside the nucleus, the homodimer GC/GCR complex binds to specific DNA binding-sites known as glucocorticoid response elements (GREs) resulting in gene expression or inhibition. Complex binding to positive GREs leads to synthesis of anti-inflammatory proteins while binding to negative GREs block the transcription of inflammatory genes.