The Oxandrolone hormone does not carry any estrogenic related side effects. It does not aromatize and cannot lead to gynecomastia or water retention due to increases in estrogen levels. It further carries no progestin related activity, which again supports no estrogenic related side effects. Due to water retention being impossible with this steroid, this will decrease the risk of high blood pressure. Excess water retention can promote high blood pressure. Some steroids that do not aromatize can lead to high blood pressure, such as Trenbolone , but Anavar is rarely associated with this trait.
Cytokines: Cytokines are a complex group of immunoregulatory proteins that exert physiological and pathological effects throughout the body. Cytokines are difficult to measure, and specific roles are relatively unknown. The role of cytokines in the development of wasting is unclear. Theories regarding the relationship between interleukin (IL)-1, IL-2, and IL-6, tumor necrosis factor alpha, and interferon gamma and the development of wasting have been postulated due to elevated levels in patients with wasting. 9 Specifically, these cytokines may encourage hypermetabolism and anorexia, promote the loss of lean body mass through enhanced protein breakdown, and even accelerate the progression from HIV to AIDS. 3,8,16 However, evidence is mixed, and therefore no clear conclusion has been reached about the importance of these cytokines in this disease. 8,9,17