Regulation of testicular steroidogenesis

The surgeon begins with four small incisions, approximately half an inch long, in the upper right side of the abdomen. Two of these incisions allow the surgeon to place surgical instruments in the abdominal cavity. The third incision is used to insert the laparoscope , an instrument that has a light and a video camera that allows the surgeon to view the surgery on a monitor while working. The fourth incision is used to insert a port that releases carbon dioxide gas, inflating the abdomen to allow better visualization and more room to work.

Surgical – For many PSS cases surgery is the treatment of choice. The abnormal vessel that is shunting blood around the liver is identified and closed (ligated) to minimize blood flowing through it. When the abnormal blood vessel is ligated blood will now flow through the liver instead of around it. This is readily accomplished for solitary extrahepatic shunts. Intrahepatic shunts can be more difficult
to identify and ligate. Post surgical monitoring is important. If the pressure within the liver becomes too high due to the increased blood flow through the liver then the ligation on the shunting vessel(s) must be reduced or removed.

Recently, a specific peptide inhibitor for ATGL was isolated from white blood cells, specifically mononuclear cells. This peptide was originally identifed as being involved in the regulation of the G 0 to G 1 transition of the cell cycle . This peptide was, therefore, called G0G1 switch protein 2 (G0S2). The protein is found in numerous tissues, with highest concentrations in adipose tissue and liver. In adipose tissue G0S2 expression is very low during fasting but increases after feeding. Conversely, fasting or PPARα-agonists increase hepatic G0S2 expression. The protein has been shown to localize to LDs, cytoplasm, ER, and mitochondria. These different subcellular localizations likely relate to multiple functions for G0S2 in regulating lipolysis, the cell cycle , and, possibly, apoptosis via its ability to interact with the mitochondrial antiapoptotic factor Bcl-2. With respect to ATGL regulation, the binding of the enzyme to LDs and subsequent is dependent on a physical interaction between the N-terminal region of G0S2 and the patatin domain of ATGL.

B4. IVF outcomes
Chair: Jason Kasraie, Chair, Association of Clinical Embryologists, UK
Novel measures of sperm DNA damage increase its usefulness to diagnose male infertility and predict live births following both IVF and ICSI – James Nicopoullos, Consultant Gynaecologist, The Lister Hospital London, UK
Male partner age influence on the pregnancy outcome after in vitro fertilisation – Ioannis Gallos, Sub-specialty Trainee in Reproductive Medicine and Associate Clinical Lecturer in Obstetrics & Gynaecology, Institute of Metabolism and Systems Research (IMSR)
The effect of alcohol, smoking and male age on semen parameters and IVF/ICSI outcome: is there a correlation? – Timothy Bracewell-Milnes, Clinical Research Fellow, Imperial College London, UK
The under-performance of overweight women during IVF is likely treatment-dependent –  Athanasios Papathanasiou, Regional Lead Clinician, Bourn Hall Clinic, UK
Cumulative live birth rates in women with low ovarian reserve are higher with IVF after ovarian stimulation than after repeated natural cycle IVF attempts – Marco Gaudoin, Medical Director, GCRM, UK
Effects of Luteal Phase Progesterone Dosage on FET Cycle Outcome – Shaun McGowan, ST5 Trainee, Belfast Health & Social Care Trust

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Regulation of testicular steroidogenesis

regulation of testicular steroidogenesis

B4. IVF outcomes
Chair: Jason Kasraie, Chair, Association of Clinical Embryologists, UK
Novel measures of sperm DNA damage increase its usefulness to diagnose male infertility and predict live births following both IVF and ICSI – James Nicopoullos, Consultant Gynaecologist, The Lister Hospital London, UK
Male partner age influence on the pregnancy outcome after in vitro fertilisation – Ioannis Gallos, Sub-specialty Trainee in Reproductive Medicine and Associate Clinical Lecturer in Obstetrics & Gynaecology, Institute of Metabolism and Systems Research (IMSR)
The effect of alcohol, smoking and male age on semen parameters and IVF/ICSI outcome: is there a correlation? – Timothy Bracewell-Milnes, Clinical Research Fellow, Imperial College London, UK
The under-performance of overweight women during IVF is likely treatment-dependent –  Athanasios Papathanasiou, Regional Lead Clinician, Bourn Hall Clinic, UK
Cumulative live birth rates in women with low ovarian reserve are higher with IVF after ovarian stimulation than after repeated natural cycle IVF attempts – Marco Gaudoin, Medical Director, GCRM, UK
Effects of Luteal Phase Progesterone Dosage on FET Cycle Outcome – Shaun McGowan, ST5 Trainee, Belfast Health & Social Care Trust

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