The liver receives a dual blood supply from the hepatic portal vein and hepatic arteries . The hepatic portal vein delivers approximately 75% of the liver's blood supply, and carries venous blood drained from the spleen , gastrointestinal tract , and its associated organs. The hepatic arteries supply arterial blood to the liver, accounting for the remaining quarter of its blood flow . Oxygen is provided from both sources; approximately half of the liver's oxygen demand is met by the hepatic portal vein, and half is met by the hepatic arteries. 
Macroscopically, the liver is initially enlarged, but with the progression of the disease, it becomes smaller. Its surface is irregular, the consistency is firm, and the color is often yellow (if associated with steatosis ). Depending on the size of the nodules, there are three macroscopic types: micronodular, macronodular, and mixed cirrhosis. In the micronodular form (Laennec's cirrhosis or portal cirrhosis), regenerating nodules are under 3 mm. In macronodular cirrhosis (post-necrotic cirrhosis), the nodules are larger than 3 mm. Mixed cirrhosis consists of nodules of different sizes.