Stimulation of collagen synthesis by the anabolic steroid stanozolol

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Sutbeyaz et al (2006) assessed the effect of PEMF on pain, range of motion (ROM) and functional status in patients with cervical osteoarthritis (COA).  A total of 34 patients with COA were included in a randomized, double-blind study, in which PEMF was administrated to the whole body using a mat x m in size.  During the treatment, the patients lay on the mat for 30 mins per session, twice a day for 3 weeks.  Pain levels in the PEMF group decreased significantly after therapy (p < ), but no change was observed in the placebo group.  The active ROM, paravertebral muscle spasm and neck pain and disability scale scores improved significantly after PEMF therapy (p < ) but no change was observed in the sham group.  The results of this study are promising, in that PEMF treatment may offer a potential therapeutic adjunct to current COA therapies in the future.

Santamato et al (2012) stated that frequency rhythmic electrical modulation system (FREMS) is an innovative type of transcutaneous electrotherapy used in a rehabilitation setting for the treatment of pain, especially in diabetic patients.  In a randomized clinical trial (RCT), these researchers tested the hypothesis that FREMS is effective in the treatment of chronic and painful venous leg ulcers in 20 older patients.  Group A (n = 10) received FREMS and topical treatment, whereas group B (n = 10) received topical treatment alone.  Over a period of 3 consecutive weeks, 15 treatment sessions were done for each group.  Wound healing and tissue repair were evaluated with the Visitrack digital planimetry system and photos.  Pain was evaluated using the visual analog scale (VAS).  The measurements were done at baseline and after 5, 10, and 15 days of treatment, with follow-up measurements after 15 and 30 days from the last treatment session.  Group A showed a statistically significant decrease in ulcer area during the treatment and follow-up.  The VAS score showed a statistically significant decrease after 5 and 10 days of treatment.  Group B showed a statistically decrease in ulcer area after 5, 10, and 15 days of treatment with a reduction of VAS score only at 15 days of follow-up.  At the end of the treatment, the comparison of the change in ulcer area and the change in VAS score of each group showed a statistically significant difference between groups, suggesting the therapeutic and analgesic effectiveness of FREMS in reducing pain and area of chronic venous leg ulcers in older adults.  Moreover, the authors concluded that further investigation is needed to determine its reproducibility in larger case series or RCTs with longer follow-up periods.

Stimulation of collagen synthesis by the anabolic steroid stanozolol

stimulation of collagen synthesis by the anabolic steroid stanozolol

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