The thing is that fenugreek extracts haven’t always performed this well on scientific studies. Although in rodents, the extract increased muscle growth, it failed to have any impact on circulating testosterone levels 5 . In an effort to replicate the first human study sponsored by Indus Biotech, Bushey et al. found that in their trial, fenugreek did not increase either free or total testosterone levels, but it ended up lowering DHT due to 5-a reductase inhibitory effect 6 . Lastly, a study using 600mg/day of fenugreek extract called “Testofen” on healthy male subjects, failed to show any increases in testosterone levels 7 .
In a performance setting, Cytomel doses will be very similar to hypothyroidism treatment plans. The individual will normally begin with 25mcg per day and increase the total dose -25mcg every 2-4 weeks as needed. Most will find they will have no need to go above 75-100mcg per day, with the 125mcg per day range being acceptable for very short periods of time. Such a high dose might be acceptable at the end of a harsh contest diet but should not be a regular dose through the brunt of the diet. As for total use, 6-8 weeks will be the safest total duration. Longer can be acceptable, such as 8-12 weeks, but it does increase the risk of thyroid dependency. However, most healthy adults should not have an issue. Once you have reached your high end dose and it’s time to come off, you are encouraged to drop the dose down to 25mcg per day and hold at that dose for 7-10 days. This will allow the body to adjust and protect you from falling into hypothyroidism. For no reason should you discontinue use abruptly, the 7-10 day low dose is imperative.